Publications

(1)     Scott R. Gilbertson and Cheng-Wei T. Chang, "Synthesis of New Disugar Phosphine Ligands and Their Use in         Asymmetric Hydrogenation." J. Org. Chem, 1995, 60, 6226.

(2)    Scott R. Gilbertson and Cheng-Wei T. Chang, "A Modular Approach to Ligands for Asymmetric p-Allyl Palladium Catalyzed Additions." J. Chem. Soc. Chem. Commun. 1997, 975.

(3)    Scott R. Gilbertson and Cheng-Wei T. Chang, " Asymmetric p-Allyl Palladium Catalyzed Additions; A Modular Approach to Phosphine-Oxazoline Ligands." J. Org. Chem, 1998, 63, 8424.

(4)    Cheng-Wei T. Chang, Xuemei H. Chen, and Hung-wen Liu, "CDP-6-deoxy-6,6'-difluoro- a-D-glucose : A mechanism-Based Inhibitor for CDP-D-glucose 4,6-Dehydratase." J. Am. Chem. Soc. 1998, 120, 9698-9699.

(5)    Chang, C.-W. T.; Johnson, D. A.; Bandarian, V.; Zhou, H.; LoBrutto, R.; Reed, G. H.; Liu, H.-w. “Characterization of A Unique Coenzyme B6 Radical in the Ascarylose Biosynthetic Pathway.” J. Am. Chem. Soc. 2000, 122, 4239-4240.

(6)    Chang, C.-W.; Zhao, L.; Yamase, H.; Liu, H.-w., “Des VI: A New Member of the Sugar N,N-Dimethyltransfrease Family Involved in the Biosynthesis of Desosamine.” Angew. Chem. Int. Ed. 2000, 39, 2160-2163.

(7)    Cheng-Wei T. Chang, Terri Clark, Mumbi Ngaara “Novel and Convenient Method for the Synthesis of 2,6-Dideoxypyranoses, 3,6-Dideoxypyranoses, and Azido (amino) Analogs of 3,6-Dideoxypyranoses” Tetrahedron Letter, 2001 , 42, 6797-6801.

(8)    Cheng-Wei Tom Chang, Yu Hui, Bryan Elchert “Studies of the Stereoselective Reduction of Ketosugar (Hexosulose).” Tetrahedron Letter, 2001, 42, 7019-7023.

(9)    Cheng-Wei T. Chang and Hung-wen Liu, "Synthesis of TDP-3-amino-3,4,6-trideoxy-a- D- xylo-hexopyranose-The immediate precursor of TDP-a- D-desosamine" Bioorg. Med. Chem. Lett. 2002, 12, 1493-1496.

(10)    Yu Hui and Cheng-Wei T. Chang " A Convenient Divergent Synthesis of A library of Trehalosamine Analogs." Org. Lett. 2002, 4, 2245-2248.

(11)     Chen, H.; Yamase, H.; Zhao, L.; Chang, Cheng-Wei T.; Zhao, K.; Murakami, K.; Liu, H.-w. "N, N-Dimetyltransferases, TylM1 and DesVI, Involved in the Biosynthesis of Mycaminose and Desosamine: Expression, Purification and Characterization ^." Biochemistry 2002, 29, 9165-9183.

(12)     Wang, J.; Li, J.; Tuttle, D.; Takemoto, J.; Chang, C.-W. T. " The synthesis of L-aminosugar and the studies of L-pyranoses on the ring III of pyranmycins." Org. Lett. 2002, 4, 3997-4000.

(13)     Hui, Y.; Ptake, P.; Paulman, R.; Pallansch, M.; Chang, C.-W. T. " Synthesis of Novel Guanidine Incorporated Aminoglycosides, Guanidinopyranmycins." Tetrahedron Lett. 2002, 43, 9255-9257.

(14)     Chang, C.-W. T.; Hui, Y.; Elchert, B.; Wang, J.; Li, J.; Rai, R. "Pyranmycins, a novel class of aminoglycosides with improved acid stability: the SAR of D-pyranoses on ring III of pyranmycin." Org. Lett.   2002, 4, 4603-4606.

(15)     Li, J.; Wang, J.; Hui, Y.; Chang, C.-W. T. "Exploring the Optimal Site for Modifications of Pyranmycins with the Extended Arm Approach" Org. Lett.  2003, 5, 431-434

(16)     Leriche, C.; He, X.; Chang, C.-W. T.; Liu, H.-w. "Reversal of the Apparent Regiospecificity of NAD(P)H-Dependent Hydride Transfer: The Properties of the Difluoromethylene Group, A Carbonyl Mimic."  J. Am. Chem. Soc., 2003; 125, 6348-6349.

(17)     Elchert, B.; Li, J.; Wang, J.; Hui, Y.; Rai, R.; Ptak, R.; Ward, P.; Takemoto, J. Y.; Bensaci, M.; Chang, C.-W. T. "Application of the Synthetic Aminosugars for Glycodiversification: Synthesis and Antimicrobial Studies of Pyranmycin." J. Org. Chem., 2004, 69, 1513-1523.

(18)     Li, J.; Wang, J.; Czyryca, P. G.; Chang, H.; Orsak, T. W.; Evanson, R.; Chang, C.-W. T. "Application of Glycodiversification: Expedient Synthesis and Antibacterial Evaluation of a Library of Kanamycin B Analogs." Org. Lett. 2004, 6, 1381-1384.

(19)     Wang, J.; Li, L.; Czyryca, P. G.; Chang, H.; Kao, J.; Chang, C.-W. T. “Synthesis of an Unusual Branched-chain Sugar, 5-C-methyl-L-idopyranose for SAR Studies of Pyranmycins: Implications for the Future Design of Aminoglycoside Antibiotics.” Bioorg. Med. Chem. Lett. 2004, 4, 4389-4393.

(20)     Wang, J.; Elchert, B.; Hui, Y.; Takemoto, J. Y.; Bensaci, M.; Wennergren, J.; Chang, H.; Rai, R.; Chang, C.-W. T. “Synthesis of Trehalose-based Compounds and Study of Their Antibacterial Activity against Mycobacterium smegmatis.” Bioorg. Med. Chem. 2004, 12, 6397-6413.

(22)     Rai, R.; Chang, H.; Chang, C.-W. T. “Novel Method for the Synthesis of 3’,4’-Dideoxygenated Pyranmycin and Kanamycin Compounds, and Studies of Their Antibacterial Activity against Aminoglycoside Resistant Bacteria.” J. Carbohydr. Chem. 2005, 24, 131-143.

(23)      Lee, S. T.; Molyneux, R. J.; Panter, K. E.; Chang, C.-W. T.; Gardner, D. R.; Pfister, J. A.; Garrossian, M. “Ammodendrine and N-Methylammodendrine Enantiomers: Isolation, Optical Rotation, and Toxicity.” J. Nat. Prod. 2005, 68, 681-685.

(24)      Li, L.; Chen, H.-N.; Chang, H.; Wang, J.; Chang, C.-W. T. “Tuning the Regioselectivity of Staudinger Reaction for the Facile Synthesis of Kanamycin and Neomycin Class Antibiotics with N-1 Modification.”  Org. Lett. 2005, .7, 3061-3064.

(25)     Rai, R.; McAlexander, I.; Chang, C.-W. T. “Synthetic Glycodiversification: from Aminosugars to Aminoglycoside Antibiotics.” Organic Preparations and Procedures International, 2005, 37, 337-375.

(26)    Wang, J.; Chang, C.-W. T. “Systematic Synthesis of Aminosugars and Their Stereoselective Glycosylation.” in Carbohydrate Drug Design, Klyosov, A. A.; Witczak, Z. J.; Platt, D. Eds., ACS Symposium Series, No. 932, 2005.

(27)    Wang, J.; Li, J.; Chen, H.-N.; Chang, H.; Tanifum, C. T.; Liu, H.-H.; Czyryca, P. G.; Chang, C.-W. T. “Glycodiversification for Optimization of the Kanamycin Class Aminoglycosides.” J. Med. Chem., 2005, 48, 6271-6285.

(28)    Deng, S.; Chang, C.-W. T. “Acyl Migration for the Construction of Disaccharides.” Synlett. 2006, 756-760.

(29)    Wang, J.; Chang, C.-W. T. “Glycodiversification for the Synthesis of Kanamycin and Neomycin Class Aminoglycoside Antibiotics.” in Frontiers in Carbohydrate Chemistry, Demchenko, A. Ed. ACS Symposium Series, volume 960, 2007, p307-327.

(30)    Li, J.; Chang, C.-W. T. “Recent Development in the Synthesis of Novel Aminoglycoside Antibiotics” Anti-Infective Agents in Medicinal Chemistry 2006, 5, 255-271.

(31)    Wang, J.; Chang, C.-W. T. “Design, Chemical Synthesis, and Antibacterial Activity of Kanamycin and Neomycin Class Aminoglycoside Antibiotics.” in Aminoglycoside Antibiotics Arya, D. P. ed., John Wiley & Sons, Inc. 2007, p141-180.

(32)    Lee, S. T.; Wildeboer, K.; Panter, K. E.; Kem, W. R.; Gardner, D. R.; Molyneux, R. J.; Chang, C.-W. T.; Soti, F.; Pfister, J. A. “Relative toxicities and neuromuscular nicotinic receptor agonistic potencies of anabasine enantiomers and anabaseine.” Neurotoxicology and Teratology 2006, 28, 220-228.

(33)    Rai, R.; Chen, H.;  Czyryca, P. G.; Li, J.; Chang, C.-W. T. “Design and Synthesis of Pyrankacin: A Pyranmycin Class Broad Spectrum Aminoglycoside Antibiotic.” Org. Lett. 2006, 8, 887-889.

(34)    Deng, S.; Gangadharmath, U.; Chang, C.-W. T. “Sonochemistry: A Powerful Way of Enhancing the Efficiency of Carbohydrate Synthesis.” J. Org. Chem. 2006, 71, 5179-5185.

(35)    Mattis, V.; Wang, J.; Rai, R.; Chang, C.-W. T.; Lorson, C. L. “Identification of novel aminoglycosides that stimulate Survival Motor Neuron protein levels in Spinal Muscular Atrophy fibroblasts.” Human Genetics 2006, 120, 589-601.

(36)    Zhang, J.; Chen, H.-N.; Chiang, F.-I.; Takemoto, J. Y.; Bensaci, M.; Chang, C.-W. T. "Sonication-Assisted Library Synthesis of Oxazolidinone-Carbohydrate Conjugates." J. Comb. Chem. 2007, 9, 17-19.

(37)    Li, J.; Chiang, F.-I.; Chen, H.-N.; Chang, C.-W. T. “Investigation of the Regioselectivity for Staudinger Reaction and Its Application for the Synthesis of Aminoglycosides with N-1 Modification.” J. Org. Chem. 2007, 72, 4055-4066.

(38)    Li, J.; Wang, J.; Chiang, F.-I.; Chen, H.-N.; Chang, C.-W. T. “Synthesis of Pyranmycin Derivatives with N-1 and O-6 Modifications.” Bioorg. Med. Chem. 2007, 15, 7711-7719.

(39)    Zhang, J.; Garrossian, M.; Gardner, D.; Garrossian, A.; Chang, Y.-T.; Kim, Y. K.; Chang, C.-W. T. “Synthesis and Anticancer Activity Studies of Cyclopamine Derivatives.” Bioorg. Med. Chem. Lett. 2008, 18, 1359–1363.

(40)    Lee, S. T.; Gardner, D. R.; Chang, C.-W. T.; Panter, K. E.; Molyneux, R. J. “Separation of Measurement of Plant Alkaloid Enantiomers by RF-HPLC Analysis of Their Fmoc-Alanine Analogs.“ Phytochem. Anal. 2008, 19, 395-402.

(41)    Zhang, J.; Chiang, F.-I.; Wu, L.; Czyryca, G. P.; Li, D.; Chang, C.-W. T. “Surprising Alteration of Antibacterial Activity of 5"-Modified Neomycin against Resistant Bacteria.” J. Med. Chem. 2008, 51, 7563-7573.

(42)    Zhang, J.; Chang, C.-W. T. “Divergent Synthesis of Three Classes of Aryl N-Glycosides by Solvent Control.” J. Org. Chem. 2009, 74, 685-695.

(43)    Tanifum, C. T.; Chang, C.-W. T. “Sonication-Assisted Oligomannosides Syntheses.” J. Org. Chem. 2009, 74, 634-644.

(44)    Zhang, J.; Chang, C.-W. T. “One-pot Synthesis of 1- and 2-Substituted Naphtho[2,3-d][1,2,3]triazole-4,9-diones” J. Org. Chem. 2009, 74, 4414-4417.

(45)    Chang, C.-W. T. “Predictable Enzymatic Glycosylation.” Chem. Biol. 2009, 16, 579-580.

(46)    Zhang, J.; Keller, K.;  Takemoto, J. Y.; Bensaci, M.; Litke, A.; Czyryca, P. G.; Chang, C.-W. T. “Synthesis and Combinational Antibacterial Study of 5"-Modified Neomycin” J. Antibiot. 2009, 62, 539-544..

(47)    Mattis, V. B.; Ebert, A. D.; Fosso, M. Y.; Chang, C.-W. T.; Lorson, C. L. “Delivery of a read-through inducing compound, TC007, lessens the severity of a SMA animal model.” Human Molecular Genetics 2009, 18, 3906-3913.

(48)    Zhang, J.; Litke, A.; Keller, K.; Rai, R.; Chang, C.-W. T. “Synthesis of Novel Aminoglycosides via Allylic Azide Rearrangement for Investigating the Significance of 2'-Amino Group.” Bioorg. Med. Chem. 2010, 18, 1396-1405.

(49)    Tanifum, C. T.; Zhang, J.; Chang, C.-W. T. “Combination of Solid Phase and Solution Phase Synthesis of Oligosaccharides Using Sonication.” Tetrahedron Lett. 2010, 51, 4323-4327.

(50)    Chang, C.-W. T.; Fosso, M.; Kawasaki , Y.; Shrestha, S.; Bensaci, M. F.; Wang, J.; Evans, C. K.; Takemoto, J. Y. “Converting an Antibacterial Aminoglycoside into a Fungicide via Simple Chemical Modification. New Strategy for Reviving Old Drugs.” J. Antibiot. 2010, 63, 667-672.

(51)    Zhang, J.; Redman, N.; Litke, P.; Zeng, J.; Zhan, J.; Chan, K. Y.; Chang, C.-W. T. “Synthesis and Antibacterial Activity Study of a Novel Class of Cationic Anthraquinone Analogs.” Bioorg. Med. Chem. 2011, 19, 498-503.

(52)    Chan, K. Y.; Zhang, J.; Chang, C.-W. T. “Mode of Action Investigation for the Antibacterial Cationic Anthraquinone Analogs.” Bioorg. Med. Chem. Lett. 2011, 21, 6353-6356.

(53)    Fosso, M. Y.; Chan, K. Y.; Gregory, R.; Chang, C.-W. T. "Library Synthesis and Antibacterial Investigation of Cationic Anthraquinone Analogs." ACS Comb. Sci. 2012, 14, 231−235.

(54)    Lee, S. T.; Panter, K. E.; Gardner, D. R.; Green, B. T.; Welch, K. D.; Zhang, J.; Chang, C.-W. T. "Development of a monoclonal antibody-based ELISA for the hedgehog inhibitors cyclopamine and cyclopamine-KAAD." J. Pharmaceut. Biomed. 2012, 66, 282-286.

(55)    .Mattisa, V. B.; Chang, C.-W. T.; Lorson, C. L. "Analysis of a read-through promoting compound in a severe mouse model of Spinal Muscular Atrophy." Neurosci. Lett. 2012, 525, 72-75.

(56)    Fosso, M. Y.; Nziko, V. P. N.; Chang, C.-W. T. "Chemical Synthesis of N-Aryl Glycosides." J. Carbohydr. Chem. 2012, 31, 603-619.

(57)    Udumula, V.; Ham, Y. W.; Fosso, M. Y.; Chen, K. Y.; Rai, R.; Zhang, J.; Li, J.; Chang, C.-W. T. "Investigation of Antibacterial Mode of Action for Traditional and Amphiphilic Aminoglycosides." Bioorg. Med. Chem. Lett. 2013, 23, 1671–1675. 

(58)    Ito,T.; Chen, D; Chang, C.-W. T.; Kenmochi, T.; Saito, T.; Suzuki, S.; Takemoto, J. Y. "Mesobiliverdin-IXa Enhances Rat Pancreatic Islet Yield and Function." Frontiers in Drug Metabolism and Transport, 2013, in press.

(59)    Lee, S. T.; Green, B. T.; Welch, K. D.; Jordan, G. T.; Zhang, Q.; Panter, K. E.; Hughes, D.; Chang, C.-W. T.; Pfister, J. A.; Gardner, D. R. "Stereoselective Potencies and Relative Toxicities of g-Coniceine and N-Methylconiine Enantiomers." Chem. Res. Toxicol. 2013, 26, 616−621.