"Ongoing projects are examining the chemistry of phosphoryl and sulfuryl esters. These compounds have great importance in biological systems, where their hydrolysis and their formation are catalyzed with remarkable efficiency by enzymes at rates millions of times (or more) faster than the analogous uncatalyzed reactions. Our research seeks to understand this chemistry, and how enzymes achieve these remarkable rate accelerations."

 

:: Contact

Professor Alvan Hengge
Department of Chemistry and Biochemistry
Utah State University
Logan, UT 84322-0300 USA
Office phone: (435) 797-3442, FAX: (435) 797-3390
Lab phone: (435) 797-0023
E-mail: alvan.hengge@usu.edu

:: Hotspot

Insights into the Reaction of Protein-tyrosine Phosphatase 1B: Crystal Structures for Transition State Analogs of Both Catalytic Steps
Tiago A. S. Brandao, Alvan C. Hengge, Sean J. Johnson.
J. Biol. Chem. 2010285 (21), 15874-15883.  DOI: 10.1074/jbc.M109.066951

Last update: April 16th 2010