Most of our projects are examining the chemistry of phosphoryl and sulfuryl esters. These compounds have great importance in biological systems, where their hydrolysis and their formation are catalyzed with remarkable efficiency by enzymes at rates millions of times (or more) faster than the analogous uncatalyzed reactions. Our research seeks to understand this chemistry, and how enzymes achieve these remarkable rate accelerations.

Contact:

Professor Alvan Hengge
Department of Chemistry and Biochemistry
Utah State University
Logan, UT 84322-0300 USA
Office phone: (435) 797-1620              FAX: (435) 797-3390
Lab phone: (435) 797-0023
E-mail:  alvan.hengge@usu.edu

Recent Articles:


Sean K. Whittier, Alvan C. Hengge, and J. Patrick Loria.  “Conformational Motions Regulate Phosphoryl Transfer in Related Protein Tyrosine Phosphatases.”  Science, 2013 (341), 899-903.  DOI: 10.1126/science.1241735


Alvan C. Hengge.   “Kinetic Isotope Effects In The Characterization Of Catalysis by Protein Tyrosine Phosphatases.” Biochim. Biophys. Acta.-Proteins and Proteomics 2015, 1854, 1768-1775.  DOI:  10.1016/j.bbapap.2015.03.010

See the Publications tab for a list of all articles from the Hengge lab since 2007.